Protein Details: Transient receptor potential channel mucolipin 1

Protein ID

ICDB_Pro_1502

Protein Name

Transient receptor potential channel mucolipin 1

Gene Name

MCOLN1; ML4; TRPML1; MSTP080

Organism

Homo sapiens (Human)

Length

580 amino acids

AlphaFoldDB

AF-Q9GZU1-F1-model_v4.pdb

Function

Sequence

MTAPAGPRGSETERLLTPNPGYGTQAGPSPAPPTPPEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLMLQVVKILVVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTDCIQVDPPERPPPPPSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRIPISLETQAHIQECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRVISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVIRYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGAGAEESELQAYIAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSEEHSLLVN

PDB Structures

5TJA 5TJB 5TJC 5WJ5 5WJ9 6E7P 6E7Y 6E7Z 7MGL

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Mucolipidosis Iv and Corneal Dystrophy;Lisch Epithelial

Location

Widely expressed in adult and fetal tissues

DOI ID

10.1016/s0002-9297(07)62941-3; 10.1093/hmg/9.17.2471; 10.1038/79095; 10.1038/ng1285; 10.1101/gr.2596504; 10.1016/s0014-5793(02)03670-0; 10.1016/j.bbrc.2004.08.045; 10.1016/j.febslet.2004.04.080; 10.1093/hmg/ddh067; 10.1074/jbc.m508210200; 10.1111/j.1600-0854.2006.00387.x; 10.1111/j.1600-0854.2006.00475.x; 10.1111/j.1600-0854.2007.00643.x; 10.1042/bj20070713; 10.1038/nature07311; 10.1074/jbc.m109.047241; 10.1021/pr8008012; 10.1002/jcp.21956; 10.1016/j.yexcr.2011.01.008; 10.1242/jcs.076240; 10.1073/pnas.1202194109; 10.1111/tra.12205; 10.1038/ncb3114; 10.1073/pnas.1419669112; 10.1016/j.devcel.2016.08.001; 10.7554/elife.19360; 10.1038/ncomms12109; 10.1038/nsmb.3362; 10.1038/nature24036; 10.1002/humu.1115; 10.1212/wnl.59.3.306; 10.1002/humu.20094; 10.1126/science.1133427

RefSeq

NP_065394.1;